The concept of the gene has been the central organizing theme of 20th century biology. Biology has become increasingly influential both for philosophers seeking a naturalized basis for epistemology, ethics, and the understanding of the mind, as well as for the human sciences generally. The central task of this work is to get the story right about genes and in so doing provide a critical and enabling resourse for use in the further pursuit of human self-understanding. ;The work begins with (...) a wide-ranging historical reconstruction and conceptual analysis of the meaning of "the gene" that results in defining and distinguishing two different "genes". Each of these can be seen as an heir to one of the two major historical trends in explaining the source of biological order---preformationism and epigenesis. The preformationist gene predicts phenotypes but only on an instrumental basis where immediate medical and/or economic benefits can be had. The gene of epigenesis , by contrast, is a developmental resource that provides templates for RNA and protein synthesis but has in itself no determinate relationship to organismal phenotypes. The seemingly prevalent idea that genes constitute information for traits is based, I argue, upon an unwarranted conflation of these two senses which is in effect held together by rhetorical glue. Beyond this historical, conceptual, and rhetorical inquiry the bulk of the dissertation then concerns itself with an empirically up-to-date analysis of the cell and molecular basis of biological order and of the pathological loss of same. In each of these chapters I structure my analysis with the idea in mind that the "conflated" view can be held empirically accountable. Major touchpoints in this work include the ideas of I. Kant, J. Blumenbach, K. E. von Baer, J. Muller, R. Virchow, W. Johannsen, R. Falk, J. Sapp, E. Schrodinger, M. Delbruick, G. Gamow, R. Doyle, L. Kay, S. Kauffman, E. Jablonka, J. Rothman, K. Yamamoto, P. Rous, H. Temin, J. M. Bishop, H. Harris, E. Stanbridge, D. L. Smithers, B. Vogelstein, E. Farber and H. Rubin. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 36.3 (2003) 207-222 [Access article in PDF] Burke Contra Kierkegaard:Kenneth Burke's Dialectic via Reading Søren Kierkegaard G. L. Ercolini Isaac—to his children Lived to tell the tale— Moral—with a Mastiff Manners may prevail. —Emily Dickinson Kenneth Burke employs the term dialectic throughout his works and yet, despite its profuse recurrence, the term remains ambiguous. Much secondary scholarship has focused on Burke and dialectics, and still the (...) term in Burke remains—if not already complicated—cloudy. 1 Part of the difficulty regarding this term stems from Burke's own ambiguity; another part from critics' tendency to rely on Burke's own use and definitions for clarification of this concept. The arguments have been helpful and illuminating, yet Burke's dialectic can be further clarified by going beyond what Burke means by the term by focusing on how he deploys dialectical criticism in his own work. 2 This article focuses on Burke's appropriation of the existential thinker Søren Kierkegaard as a particularly clear and remarkable instance of the operation of Burke's dialectic in his criticism. I maintain that although Burke's reading of Kierkegaard is arguably a misreading, his strategic appropriation of Kierkegaard in A Rhetoric of Motives (1950) not only serves as a clear deployment of the dialectic, but also functions as a foil against which Burke defines his own critical method. Burke's reading of Kierkegaard emphasizes the function of resolution in Burke's critical project.The current literature, although quite informative, does not put Burke's dialectic in sharp focus. Rueckert argues that Burkean dialectics "is really a branch of what Burke was to later call logology, the study of words, of language, of symbol systems" (1994, 14). Heath claims that dialectic "is an analytical tool to help us diagnose perspectives so that we can [End Page 207] examine whether they make sense and consider their implications for social relations" (1986, 162). Crusius contends that, "dialectic for Burke is the study of verbal universes, the disinterested pursuit of a vocabulary's implications" (1986, 24). While Brummett and Crusius show similarity between Hegel's and Burke's dialectic, Heath and Wess distinguish Burke's dialectic from Hegelian idealism and teleological history respectively. 3 Most of the arguments concerning Burke and dialectic focus on "The Dialectic of Constitutions" in A Grammar of Motives (1969), while A Rhetoric of Motives (1962), where Burke identifies humankind as homo dialecticus, is hardly engaged with regard to this concept. 4 Burke's working through Kierkegaard in A Rhetoric of Motives demonstrates Burke's dialectical criticism—thus providing an operational account of Burke's dialectic—and allows for his revelation of the three motives in the realm of rhetoric: the Order, the Secret, and the Kill. 5 And yet, despite this centrality of Fear and Trembling, surprisingly little has been said about Burke's Kierkegaard beyond passing mention. 6Despite editorial advice to the opposite regarding an article that would later become a part of the book, Burke evidently regarded his reading of Kierkegaard as important. Joseph Bennett, editor of Hudson Review, responded as follows to Burke's 1948 submission of the article entitled "Imagery of Killing": "I would like to request that you eliminate Kierkegaard from the article in question, confining it simply to literary exegesis and excluding the philosopher theologian." 7 Although he complied for the article, Burke retained his reading of Kierkegaard in A Rhetoric of Motives. Despite the lack of attention given to it, Burke's engagement with Kierkegaard clearly demonstrates how Burke views ethical criticism as that which resolves opposition, negation, and paradox to a higher order. Burke contra Kierkegaard The section entitled "Order" in A Rhetoric of Motives contains a detailed, twenty-three-page discussion of Kierkegaard's Fear and Trembling. In this discussion, Burke primarily attacks Kierkegaard for encouraging what Burke enigmatically and elliptically identifies as the "cult of the Kill."Burke's portrayal of Kierkegaard is hardly flattering: at the crescendo of his analysis in A Rhetoric of Motives he claims that thinking such as Kierkegaard... (shrink)

Vaccinia virus, the world's oldest vaccine, was used originally for the eradication of smallpox. It is now being genetically engineered to create new live vaccines for use against other infectious agents of medical and veterinary importance. Genes coding for antigens of several pathogens have been linked to vaccinia virus transcriptional regulatory signals and inserted into the vaccinia virus genome. The resultant recombinant viruses are infectious, express the foreign gene, stimulate specific immune responses in vaccinated animals and can protect against disease (...) caused by the corresponding pathogen. (shrink)

Using data from the Survey of the Status of Social Studies ( S4), this article describes the instructional decisions and practices of elementary teachers in two neighboring states, one where social studies is tested and another where it is not. We define students’ opportunity to learn within these states as a composite of three variables: time allocations for social studies (teacher reported instructional time), methods for teaching social studies (teacher reported instructional strategies), and content focus (teacher reported content emphases and (...) state-mandated curriculum standards). Our guiding research question for this study was: To what extent do teachers’ perceptions of elementary school social studies instructional practices and content vary between two states with different testing policies for social studies? Initial findings revealed notable differences that could not be explained by testing policies alone. Therefore, we conducted an exploratory content analysis of the elementary social studies curricula in these neighboring states. We uncovered curricular differences that suggest that state standards influence teachers’ decisions in both what and how they choose to teach social studies. However, there were curriculum differences that did not align with S4 instructional methods and content focus output. Thus, we concluded that other factors apart from the curriculum guide teachers’ decision-making. Results provided evidence that students have different opportunities to learn based on (1) state testing policies in social studies, (2) curriculum content, (3) how social studies is delivered (e.g., stand-alone versus integration), and (4) time allocated to social studies. We concluded that these variables constrict or expand students’ opportunity to learn social studies and may influence teachers’ pedagogical and content choices in elementary social studies. (shrink)

Infectious disease outbreaks in residential care are complex to manage and difficult to control. Research in this setting that includes individuals who lack capacity must conform to national legislation. We report here on our study that is investigating outbreaks of scabies, an itchy skin infection, in the residential care setting in the southeast of England. There appears to be a gap in legislative advice regarding the inclusion of people who lack capacity in research that takes place during time-limited acute scenarios (...) such as outbreaks. We received inconsistent advice from experts regarding, in particular, the role of nominated consultees. There is a potential inequality for vulnerable populations who cannot themselves provide informed consent in terms of their access to participation in a range of health-related research. (shrink)

Isolated neutron stars undergoing non-radial oscillations are expected to emit gravitational waves in the kilohertz frequency range. To date, radio astronomers have located about 1,300 pulsars, and can estimate that there are about 2×108 neutron stars in the galaxy. Many of these are surely old and cold enough that their interiors will contain matter in the superfluid or superconducting state. In fact, the so-called glitch phenomenon in pulsars (a sudden spin-up of the pulsar's crust) is best described by assuming the (...) presence of superfluid neutrons and superconducting protons in the inner crusts and cores of the pulsars. Recently there has been much progress on modelling the dynamics of superfluid neutron stars in both the Newtonian and general relativistic regimes. We will discuss some of the main results of this recent work, perhaps the most important being that superfluidity should affect the gravitational waves from neutron stars (emitted, for instance, during a glitch) by modifying both the rotational properties of the background star and the modes of oscillation of the perturbed configuration. Finally, we present an analysis of the so-called zero-frequency subspace (i.e., the space of time-independent perturbations) and determine that it is spanned by two sets of polar (or spheroidal) and two sets of axial (or toroidal) degenerate perturbations for the general relativistic system. As in the Newtonian case, the polar perturbations are the g-modes which are missing from the pulsation spectrum of a non-rotating configuration, and the axial perturbations should lead to two sets of r-modes when the degeneracy of the frequencies is broken by having the background rotate. (shrink)

Previous research has examined the role of formal classroom economics education on student learning. However, few studies have examined the role of both in school and out of school economics education exposure on student learning. Using data from the 2006 National Assessment of Educational Progress (NAEP)-Economics 12th grade assessment, we conducted an analysis using multilevel modeling to examine both student- and school-level effects on economics content knowledge. We analyzed the relationship among student-level variables including demographics, economics course structure, and instructional (...) exposure. Unlike prior studies, we accounted for the nesting of students in schools and determined significant building-level effects associated with NAEP-E outcomes. We included district and state accountability policies (e.g., required testing and graduation requirements) as well as contextual variables (e.g., percent minority and percent college bound) at the building level. Findings offered a more nuanced interpretation of earlier NAEP-E studies and extended earlier analyses to include instructional exposure and building-level effects. (shrink)

Don Carlos de Sigüenza y sor Juana Inés de la Cruz no solo se encuentran en la encrucijada del paso de la edad media a la moderna, y del viejo al nuevo mundo, sino de la vieja a la nueva vía de reflexión y de la vieja a la nueva ciencia. Es lo que se intenta mostrar en estas páginas.

Making data broadly accessible is essential to creating a medical information commons. Transparency about data-sharing practices can cultivate trust among prospective and existing MIC participants. We present an analysis of 34 initiatives sharing DNA-derived data based on public information. We describe data-sharing practices captured, including practices related to consent, privacy and security, data access, oversight, and participant engagement. Our results reveal that data-sharing initiatives have some distance to go in achieving transparency.

In REG 73 and 75 I discussed various points connected with the Peace of Philocrates, a number of which have been assailed by M. M. Markle in CQ N.S. 24 in an article entitled ‘The Strategy of Philip in 346 B.C.’. Time passes, and, although de Ste. Croix in his Origins of the Peloponnesian War , p.105, felt able to declare that ‘a book shortly to be published by M. M. Markle makes a valuable and original contribution to our understanding (...) of the Peace of Philocrates’, and Markle himself confirms that a book is indeed forthcoming, some comment on his preliminary comments may be permitted. (shrink)

The title of this presentation may suggest that the subject is homocystinuria. It is not. Rather, the subject is how our epistemology influences our concept of disease, which in turn determines our ability to help patients.